For The Athlete
Alpha-Ketoglutaric Acid acid plays a vital role in the Krebs cycle, the system utilized by the body to release large amounts of energy. Alpha-Ketoglutaric Acid is also a precursor to the amino acid glutamic acid (a non-essential amino acid that can be synthesized in the body) that is involved in protein synthesis (proteogenic) and can be converted to glucose (glycogenic). Glutamic acid actually helps to stabilize blood glucose levels, particularly during exercise, fasting or very low calorie diets.
Alpha-ketoglutaric acid may prove an important adjunct to proper diet and training for the athlete desiring peak performance. Studies have shown that ammonia formed in the muscles, kidney and brain combines with alpha-ketoglutarate and L-glutamate in order to reduce ammonia toxicity. Studies which supplemented patients after surgery with alpha-ketoglutarate found that it caused reductions in the loss of lean body mass as well as a nitrogen sparing effect.
An Ammonia Buffer To Reduce Ammonia Toxicity
Physical activity increases ammonia production in muscle. The amount of ammonia produced is proportionate to the intensity of the exercise. During exercise, skeletal muscle adds ammonia to the blood, liver and brain tissue. Several studies suggest that a decrease in blood ammonia level during exercise may increase an individual's capacity for exhaustive activity. Thus, a drop in blood ammonia could enable the athlete to sustain more intense exercise for a longer period of time. Ammonia is absorbed from the intestine into the blood and carried directly to the liver. The liver functions as the most important organ in the removal and detoxification of circulating ammonia under normal conditions. Blood leaving the liver should be virtually free of ammonia. If excess ammonia from the circulation is not removed this can cause a toxic effect to the central nervous system and can interfere with skeletal muscle activity. During exercise there is more ammonia being produced by the muscle, and yet, the liver's capacity to clear ammonia is restricted. It is suggested that the muscle adapts for an improved ammonia clearance when the liver's capacity to detoxify ammonia is compromised: during exercise, the amount of alpha-ketoglutaric acid in the skeletal muscle increases and acts as an ammonia buffer.
Alpha-Ketoglutaric Acid May Reduce The Loss Of Lean-Body Mass
The loss of skeletal muscle mass can be seen in patients after surgery. Studies show that the use of supplemented alpha-ketoglutaric acid in the intravenous nutrition of these patients prevented the decline of protein synthesis that usually occurs after surgery and prevented a negative nitrogen balance. It has been hypothesized that alpha-ketoglutarate has a nitrogen sparing effect. It is important for athletes working toward increasing lean body mass to be in positive nitrogen balance. There is positive nitrogen balance when the build up or anabolism of tissue protein is greater then the breakdown or catabolism of the tissue protein. Alpha-ketoglutaric acid may be beneficial to the athlete as the result of two key properties. It may allow for more intense, longer workouts by decreasing blood ammonia levels and may promote nitrogen balance.
Alpha-Ketoglutaric Acid from Integrated Health. Each capsules contains 500 mg. of U.S.P. Alpha-Ketoglutaric Acid. This nutrient is the finest quality available, with NO coloring agents, corn, wheat, sugar, starch, yeast, soy, meat products, artificial flavoring or preservatives.
Suggested Use: One (1) capsule 10 to 30 minutes prior to workout, and one (1) capsule 30 minutes after workout with food, or as directed by a health practitioner.
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