When we attempt to diet, our body works against us by slowing our metabolic rate in order to conserve body fat. Any time we go off our diet, we quickly accumulate more fat because our body is evolutionarily programmed to think another "famine" (diet) could strike at any time. By using thermogenic enhancing agents, our body maintains a high metabolic rate that causes us to burn the food we eat as energy rather than store it as fat.
In a more recent study in the international Journal of Obesity (May l991), aspirin potentiated the thermogenic response of ephedrine during a meal eaten by obese women, but not lean women. This study helps to explain why people with high metabolic rates can eat all they want without gaining any weight, while it's almost impossible for those with low metabolic rates to lose weight. These findings suggest that enhanced metabolic rate will increase thermogenesis, leading to fat being burned as energy rather than stored for future use.
A study in the International Journal of Obesity Related Metabolic Disorders (Feb. 1993) showed that ephedrine increases the release of brain catecholomines to enhance thermogenesis, without significant cardiovascular effects. This article cited other studies, in both animals and humans, showing that aspirin interferes with modulators that normally inhibit ephedrine's thermogenic effect. The researchers concluded that varying combinations of ephedrine and aspirin could provide "a safe combination with the necessary thermogenic properties to assist in the management of obesity". In the same issue, there was another study about the combination of ephedrine, caffeine and aspirin. These agents were investigated in a randomized, double blind, placebo controlled trial. It was concluded that fairly high doses of ephedrine, caffeine and aspirin were "well tolerated in otherwise healthy obese subjects and this combination supports modest, sustained weight loss even without prescribed caloric restriction, and may be more effective in conjunction with restriction of food intake". in reviewing these studies, the consensus is that a combination of ephedrine, caffeine and aspirin is required to produce a significant weight loss effect. Caffeine and aspirin modulate activities in the body that would normally inhibit ephedrine's thermogenic, weight loss effect.
Second, you want to take the most effective combination of natural ephedra or ephedra/caffeine containing herbs along with cofactors to enhance the weight loss effects and to protect you from any effects caused by increasing your metabolic rate. For the first week or two, you may experience a significant appetite suppressing effect from these agents. This appetite suppressing effect will produce weight loss. Your body will develop tolerance to this appetite suppressing effect, but by then the thermogenic effect will begin to kick in. You can eat a normal diet and still lose weight with ephedra and aspirin. If you want to lose weight by reducing your caloric intake, this combination make sure your metabolism doesn't slow down in response to your reduced caloric intake.
Once it's been determined that you can tolerate aspirin, you need to ascertain if you can tolerate ephedrine-caffeine. Consult your physician if you are taking asthma medications, appetite suppressing drugs, antidepressants, or cardiovascular medications. You should not take this combination if you have cardiovascular disease (especially cardiac arrhythmias), diabetes, prostatic hypertrophy, glaucoma, psychosis, or thyroid disease. You shouldn't use this combination within 14 days after taking classical MAO inhibiting drugs (deprenyl is not a classical MAO inhibitor).
If you have high blood pressure, or are a non-insulin dependent diabetic because of too much body fat, you may want to work with your doctor to adjust your medication so that you can use thermogenic enhancers to lose enough weight so that you are no longer hypertensive and/or diabetic. Pregnant and lactating women should avoid this combination.
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