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Nature's Perfect Diet Supplement


It's rare to find a new weight-loss product that offers more than one mechanism of action. Most products help you lose weight in just one of three possible ways - by suppressing your appetite, by boosting your energy level, or by blocking the absorption of dietary fats. The problem with single-acting weight-loss products is that your body soon adjusts to the product and reverses the weight-loss process.

CitriChrome is a unique multi-nutrient formula combining HCA (Hydroxy-citric Acid) derived from Garcinia cambogia, with two highly potent forms of chromium, Niacin bound chromium and chromium picolinate. CitriChrome is a unique, multiple-action weight-loss formula and one of the most advanced and weight-loss products that is currently available on the market.

Numerous scientific studies have shown that HCA effectively curbs your appetite, reduces food intake, inhibits the process by which your body produces fat (lipogenesis), and lowers fat and cholesterol levels with-out the adverse side effects caused by FDA approved weight-loss drugs. Most people attempting to lose weight struggle with diets only to find that the weight lost comes back faster than it came off. This rebound effect is caused by the body either increasing its appetite for fattening foods or by decreasing the efficiency of the process for converting food into energy.


HCA is an organic acid similar to the citric acid found in oranges, lemons, limes, and other citrus fruits. HCA is found in only a few plant species, with Garcinia Cambogia, a small, pumpkin-shaped, orange-sized fruit popular in Asia, having the highest HCA content (10%-30% by weight). Acute toxicity studies show that HCA is safer than citric acid. Furthermore, HCA has a long history of use in foods as a spice and food preservative.


When we eat, carbohydrates from our diet are digested and broken down into glucose, the special blood sugar the body uses for energy. However, when your caloric intake exceeds your body's energy needs, this excess is converted into fats by an enzyme called ATP-citrate lyase.

HCA exerts its anti-obesity effects by safely inhibiting the body's production of ATP-citrate lyase. This reduces the formation of acetyl coenzyme A, a key biochemical, which plays a critical role in energy storage. Now, instead of wasting energy to synthesize fat, energy is diverted to the production of glycogen in the liver and muscles. This slows production of LDLs and triglycerides, with the net effect of reduced fat production and storage.

Weight gain occurs when your limited capacity for storing glycogen in your liver is reached. At this point, excess glucose is converted into fat and stored in fat cells throughout your body. The HCA in CitriChrome inhibits this process by binding tightly to ATP-citrate lyase to reduce your body's production of fat and cholesterol. HCA also increases the ability of your liver and muscles to synthesize and store glycogen, which in turn suppresses your appetite and cravings for food. Studies show that HCA reduces food consumption by about ten percent.


An important difference between HCA and FDA approved weight loss drugs is that HCA is a natural compound derived from a native fruit-bearing plant rather than an artificial agent synthesized in the laboratory. The pharmaceutical giant, Hoffman LaRoche, studied HCA extensively during the 1970s and 80s, with excellent results, but chose not to pursue FDA approval because of manufacturing problems in achieving a standardized dose of HCA.

Another difference between HCA and most FDA-approved weight loss drugs is that HCA does not act on your central nervous system (CNS). FDA-approved prescription drugs such as amphetamine, methamphetamine, diethylpropion, phenmetrazine, and fenfluramine, as well as over-the-counter weight-loss drugs, all act directly upon the CNS to inhibit the endocrine mechanisms that regulate appetite, hunger, and satiety.

The major disadvantage of these compounds is that over time your body tends to develop a tolerance for them. This in turn can lead to the "rebound" effect after weight has been lost. Moreover, they can produce adverse side effects such as depression, nervousness, insomnia, and rapid heart beat (tachycardia) in over-weight people who cannot use these products.

CitriChrome contains niacin-bound chromium, a compound that has shown great ability to lower the serum cholesterol levels of college age athletes at Auburn and Georgia Southern Universities by an average of 14% and has received a U.S. patent for its ability to lower cholesterol. A 1981 study of 23 healthy adult men found a significant rise in beneficial HDL cholesterol and a reduction in body weight following 12 weeks of supplementation with 200 micrograms per day of niacin-bound chromium (Amer J Clin Nutr, 34:12:26702678:1981).

Niacin-bound chromium is just one of two forms of chromium included in CitriChrome to help produce the multiple action weight-reducing ability of HCA. The second form of chromium in CitriChrome is chromium picolinate, which has also shown the ability to induce weight-loss in scientific studies in athletes. A group of 37 men and 22 women took part in a beginners weight-training program at Louisiana State University. They were given either 200 micrograms of chromium picolinate or a placebo. Both groups receiving the extra chromium lost an average of 22% body fat and gained 42% lean body mass.


Extensive trials show that HCA should be taken 20 to 30 minutes before meals to be effective, although it can remain active for several hours afterwards. Trials also show that HCA is 700% more effective when taken two to three times per day than when taken only once. This data suggests that higher doses of HCA may be even better.


Some people find it extremely difficult to lose weight because they are genetically predisposed for rapid weight gain. Such people have an extra supply of fat cells and a slow-acting metabolism that favors the rapid deposition of body fat. The best animal model to study the extreme tendency towards obesity in humans is the genetically obese Zucker rat, which has an extended period of fat-cell proliferation compared to normal rats. (Brit J Nutr, 36:457-469: 1976).

When scientists at Columbia University's College of Physicians and Surgeons gave both lean and genetically obese Zucker rats HCA in their diet (52.6 mmol/kg) for 39 days, both lean and obese rats exhibited "a significant reduction in weight gain and food intake throughout the treatment period" compared to ad libitum-fed controls. In fact, "the rate of food consumption...was reduced by 50% in obese and lean groups." (Amer J Physiol, 240:E72-E78:1981)

When HCA treatment was discontinued during a seven-week post-treatment period, the food intake of both groups returned to normal. This produced some weight gain in both groups, "but the treated groups did not catch up to the control groups." No "rebound" eating was observed after HCA treatment, which appeared to produce permanent weight-loss in these animals. The weight loss in the lean animals was caused by a reduction in total body fat, including the number and size of their fat cells.

In the genetically obese rats, however, the decrease in weight was attributable solely to a reduction in fat cell number. While the genetically obese rats were still overweight, they underwent significant weight loss. Since these rats are resistant to weight-loss (as are their human counterparts), this suggests that HCA may be the first weight-loss agent that provides hope for people who have difficulty in losing weight even if they starve themselves."


There have been a number of studies showing that HCA can reduce food intake leading to significant weight loss in lean and obese rats, mice, and chickens. When HCA was given to mature rats (10-14 months of age), for example, food intake was reduced significantly for the first seven weeks of treatment, but not during the last seven weeks of treatment. (Amer J Clinical Nutrition, 30:767-776, 1977). Analysis of the body composition of the rats treated with HCA revealed a significant reduction in total body fat. but no change in total body protein.

The striking thing about the findings of this study is that, the normalization of food intake observed during the last seven weeks of the study did not produce the "rebound" weight gain that normally occurs after weight is lost with FDA-approved weight-loss drugs. It appeared as if HCA can induce weight loss in a physiologically natural manner without putting undue stress on the animal losing weight. The fact that the animals lost body fat, but not protein, indicates that HCA's weight-loss effect was caused by a reduction in fat, not lean body mass.


Thus far, the study of HCA in humans has been limited to trials at the University of South Carolina and the University of Arizona showing that HCA has no adverse side effects, and a double-blind study in 1991 by Dr. Anthony Conte, a Hilton Head, South Carolina physician. Dr. Conte studied 22 obese volunteers, using the combination of HCA, niacin-bound chromium, and a calorie restricted diet. Dr. Conte found that, over a two-month period, subjects who took the HCA/chromium combination lost an average of 11 pounds compared to an average loss of only 4 pounds in control subjects. (The Bariatrician, Summer, 1993, p. 17-19).


A common condition in overweight people is insulin resistance in which their tissues become insensitive to the pancreatic hormone insulin, which transports glucose and other vital nutrients into our cells for energy production and tissue growth. Insulin resistance in the obese is especially evident in muscle, adipose, liver, and brain tissue and is believed to be one of the causes of the excessive fat storage found in such individuals.

One of the best methods of enhancing the function of insulin in metabolizing sugar, fat, and protein is the essential trace mineral chromium, which is not present in adequate amounts in the diet of most Americans. Clinical trials have shown that chromium lowers blood cholesterol and glucose levels and inhibits a process known as glycosylation, in which protein molecules bind with sugar molecules to form non-functional structures that eventually cause some of the degenerative changes of aging.

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